Antidepressants in Older Adults Complexities, Confounds and Clinical Effects
D.P. Devanand, M.D., Steven P. Roose, M.D.
Older adults with depression are often treated with antidepressant medications, but there is only limited evidence from controlled trials to support their efficacy. The high frequency and severity of concurrent illness and medications in older adults with depression often makes the risk-benefit ratio difficult to calculate. Several reports in this issue are relevant to this ongoing dialectic, both in depressed patients without significant cognitive impairment and in patients with dementing illnesses who manifest depressive symptomatology.
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