برای مشاهده بهتر سایت : لینک دانلود FireFox

مقالات

 Evidence for effective interventions to reduce mental health-related stigma and discrimination in the medium and long term: systematic review

 Systematic synthesis of barriers and facilitators to service user-led care planning

 Calibrating well-being, quality of life and common mental disorder items: psychometric epidemiology in public mental health research

 Community factors influencing child and adolescent depression: A systematic review and meta-analysis

 Epidemiology, neurobiology and pharmacological interventions related to suicide deaths and suicide attempts in bipolar disorder: Part I of a report of the International Society for Bipolar Disorders Task Force on Suicide in Bipolar Disorder

 The thalamus as a putative biomarker in neurodegenerative disorders

 Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders

 Youth social withdrawal behavior (hikikomori): A systematic review of qualitative and quantitative studies

 Using the Delphi expert consensus method in mental health research

 Tea consumption and the risk of depression: A meta-analysis of observational studies

 Developing a roadmap for the translation of e-mental health services for depression

 Carcinogenicity of psychotropic drugs: A systematic review of US Food and Drug Administration–required preclinical in vivo studies

 Consensus statements on adherence issues in schizophrenia for Hong Kong

 The use of clinical and biological characteristics to predict outcome following First Episode Psychosis

 Stimulant use disorders in people with psychosis: A meta-analysis of rate and factors affecting variation

 Help-seeking behaviour and adolescent self-harm: A systematic review

 The impact of 5-HTTLPR on acute serotonin transporter blockade by escitalopram on emotion processing: Preliminary findings from a randomised, crossover fMRI study

 Phenomenological predictors of psychosocial function in bipolar disorder: Is there evidence that social cognitive and emotion regulation abnormalities contribute

نظرسنجی

نظر شما در مورد سایت چیست؟



The impact of 5-HTTLPR on acute serotonin transporter blockade by escitalopram on emotion processing: Preliminary findings from a randomised, crossover fMRI study

The impact of 5-HTTLPR on acute serotonin transporter blockade by escitalopram on emotion processing: Preliminary findings from a randomised, crossover fMRI study

 

A B S T R A C T

Objective: Benefit from antidepressant treatment such as selective serotonin reuptake inhibitors (SSRIs) may depend on individual differences in acute effects on neural emotion processing. The short (‘S’) allele of the serotonin transporter (5-HTT)-linked polymorphic region (5-HTTLPR) is associated with both negative emotion processing biases and poorer treatment outcomes. Therefore, the aim of the present study was to explore the effects of 5-HTTLPR on the impact of the SSRI escitalopram during processing of positive and negative emotional images, as well as neutral stimuli

Methods: The study employed a double-blind, randomised, placebo-controlled crossover design on 36 healthy Caucasian female participants who underwent functional magnetic resonance imaging (fMRI) scanning following placebo or escitalopram treatment, separated by a 7-day washout period

Results: Changes in the left amygdala signal with escitalopram treatment during processing of emotional stimuli were linearly related to the 5-HTTLPR ‘S’ allele load such that the signal to positive stimuli decreased and the signal to negative stimuli increased with an increasing number of low-expressing ‘S’ alleles. While 5-HTTLPR subgroups were small in size, individual subject changes with treatment and task condition increase confidence in the findings

Conclusions: While preliminary, our findings comprise the first pharmacogenetic study demonstrating an effect of the 5-HTTLPR ‘S’ allele load on escitalopram-induced changes in amygdala activity during emotional processing, consistent with a 5-HTT expression dosage model. The present findings have implications for the impact of this polymorphism on antidepressant efficacy in patients with mood and anxiety disorders

برای دریافت مقاله به طور کامل کلیک کنید.

عنوان نظر :
نام شما :
ایمیل :

آموزش

 نمرات استاژرها مرداد 1398

 نمرات اینترنها مرداد 1398

 نمرات اینترنها تیر 1398

 نمرات اینترنها خرداد 1398

 نمرات استاژرها اردیبهشت 1398

 نمرات اینترنها اردیبهشت 1398

 نمرات تئوری استاژرها خرداد ماه 1398

 نمرات استاژرها فروردین 1398

 نمرات اینترنها فروردین 1398

 نمرات استاژرها اسفند 1397

 نمرات اینترنها اسفند 1397

 نمرات استاژرها بهمن 1397

 نمرات اینترنها بهمن 1397

 نمرات اینترنها دی 1397

 نمرات امتحان تئوری استاژرها دی ماه 1397

 اختلالات سوماتوفرم

 اختلالات سایکوتیک

 فرمت شرح حال روانپزشکی

 PTSD-نیلوفر فخرالدین

 مورنینگ استاژری اسفند ۹۵

 نمونه شرح حال (مریم حاجی قاسم- استاژر)POWER POINT

 شرح حال برتر ( اینترن نجفی زادگان )

 Personality Disorders(دکتر شریعت پناهی)

 شرح حال برتر (اینترن هدیه جباری)

 اختلالات روانپزشکی اطفال ( دکتر ایمانی )

 شرح حال برتر (مانا فرحناک و مهسا امیرزرگر-اینترن)

 نمونه شرح حال برتر (پرستش ستاری - اینترن)

 نمونه شرح حال برتر (فائزه فرهادی - اینترن)

 عناوین پایان نامه های دکتر فدایی

 عناوین پایان نامه های دکترمعنوی

 عناوین پایان نامه های دکترشریعت پناهی

 عناوین پایان نامه های دکتر بنی اسد

 عناوین پایان نامه های دکتر بدر